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  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriodInterval" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriodInterval" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="sibn_SocialSecurityTaxEmployerDeferralCARESAct" abstract="false" name="SocialSecurityTaxEmployerDeferralCARESAct" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax" abstract="false" name="AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_DebtInstrumentPeriodicPaymentInterestOnlyPeriod" abstract="false" name="DebtInstrumentPeriodicPaymentInterestOnlyPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax" abstract="false" name="AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_SaleOfStockNumberOfSharesIssuedInTransactionIncludingSharesInSecondaryOffering" abstract="false" name="SaleOfStockNumberOfSharesIssuedInTransactionIncludingSharesInSecondaryOffering" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="sibn_SecondFollowOnPublicOfferingMember" abstract="true" name="SecondFollowOnPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_ProceedsFromSaleOfMarketableSecurities" abstract="false" name="ProceedsFromSaleOfMarketableSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_EmployeeStockPurchasePlanSharesMember" abstract="true" name="EmployeeStockPurchasePlanSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_A2018EmployeeStockPurchasePlanMember" abstract="true" name="A2018EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_RelatedPartyTransactionTermOfAgreement" abstract="false" name="RelatedPartyTransactionTermOfAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="sibn_EmergingGrowthCompanyExtendedTransitionPeriodPolicyPolicyTextBlock" abstract="false" name="EmergingGrowthCompanyExtendedTransitionPeriodPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="sibn_MarketableSecuritiesFairValue" abstract="false" name="MarketableSecuritiesFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_DebtInstrumentFeeAmountAsPercentageOfAggregatePrincipal" abstract="false" name="DebtInstrumentFeeAmountAsPercentageOfAggregatePrincipal" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_MarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" abstract="false" name="MarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_VestingOfEarlyExercisedStockOptions" abstract="false" name="VestingOfEarlyExercisedStockOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_DebtInstrumentPrepaymentPremiumYearTwoPercentage" abstract="false" name="DebtInstrumentPrepaymentPremiumYearTwoPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_CommonStockWarrantsMember" abstract="true" name="CommonStockWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtInstrumentPrepaymentPremiumYearThreeOrLaterPercentage" abstract="false" name="DebtInstrumentPrepaymentPremiumYearThreeOrLaterPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_MarketableSecuritiesAmortizedCost" abstract="false" name="MarketableSecuritiesAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_DebtPrepaymentPenaltyPeriodAxis" abstract="true" name="DebtPrepaymentPenaltyPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriods" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriods" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="sibn_ComputerAndOfficeEquipmentMember" abstract="true" name="ComputerAndOfficeEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_PrepaymentPenalty24MonthsOnMember" abstract="true" name="PrepaymentPenalty24MonthsOnMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_VariableOptionOneMember" abstract="true" name="VariableOptionOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_ProceedsFromMaturityOfMarketableSecurities" abstract="false" name="ProceedsFromMaturityOfMarketableSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_FollowOnPublicOfferingMember" abstract="true" name="FollowOnPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_ConstructionInProgressSantaClaraLeaseMember" abstract="true" name="ConstructionInProgressSantaClaraLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEarlyExerciseCommonStockSubjectToRepurchase" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEarlyExerciseCommonStockSubjectToRepurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="sibn_DevelopmentAgreementMember" abstract="true" name="DevelopmentAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_StockIssuedDuringPeriodSharesRestrictedStockUnits" abstract="false" name="StockIssuedDuringPeriodSharesRestrictedStockUnits" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="sibn_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis" abstract="false" name="AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_PrepaymentPenalty124MonthsMember" abstract="true" name="PrepaymentPenalty124MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_SVBTermLoanMember" abstract="true" name="SVBTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_ConstructionInProgressSurgicalPlacementInstrumentSetMember" abstract="true" name="ConstructionInProgressSurgicalPlacementInstrumentSetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_FollowOnPublicOfferingAndSecondaryOfferingMember" abstract="true" name="FollowOnPublicOfferingAndSecondaryOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtInstrumentPrepaymentPremiumYearOnePercentage" abstract="false" name="DebtInstrumentPrepaymentPremiumYearOnePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationVestingOfEarlyExercisedStockOptions" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationVestingOfEarlyExercisedStockOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_PharmakonTermLoanMember" abstract="true" name="PharmakonTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtInstrumentPrepaymentPenaltyPercentage" abstract="false" name="DebtInstrumentPrepaymentPenaltyPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_PrepaymentPenalty4960MonthsMember" abstract="true" name="PrepaymentPenalty4960MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_OperatingLeaseTermOfWrittenNoticeForTermination" abstract="false" name="OperatingLeaseTermOfWrittenNoticeForTermination" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:timeItemType"/>
  <xs:element id="sibn_SolarLoanAndSecurityAgreementMember" abstract="true" name="SolarLoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtPrepaymentPenaltyPeriodDomain" abstract="true" name="DebtPrepaymentPenaltyPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtInstrumentPrepaymentAllowableIncrementsPerAgreement" abstract="false" name="DebtInstrumentPrepaymentAllowableIncrementsPerAgreement" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_AllocatedPublicOfferingCosts" abstract="false" name="AllocatedPublicOfferingCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_LesseeOperatingLeaseLeaseNotYetCommencedNumberOfOptionsToExtend" abstract="false" name="LesseeOperatingLeaseLeaseNotYetCommencedNumberOfOptionsToExtend" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="sibn_OperatingLeasesFutureMinimumPaymentsDueAfterYearFour" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
