<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:878afdaa-3c75-4f4e-89a9-7f15ff154ba4,g:3338b2a2-8b47-44f3-9e8e-e0e84dd35cdf-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/Cover" xlink:type="simple" xlink:href="sibn-20220808.xsd#Cover"/>
  <link:presentationLink xlink:role="http://si-bone.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_08c4a56c-28d7-4ae9-8ebb-5e99449139c2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_DocumentType_08c4a56c-28d7-4ae9-8ebb-5e99449139c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_f96ab2bd-da11-4915-afd2-a3e73d01a0d4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_DocumentPeriodEndDate_f96ab2bd-da11-4915-afd2-a3e73d01a0d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_75ea0663-4923-4ca7-afc3-98b554b5ad3c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityRegistrantName_75ea0663-4923-4ca7-afc3-98b554b5ad3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_4dad9a79-b88b-42b2-89d5-5807bf617318" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityCentralIndexKey_4dad9a79-b88b-42b2-89d5-5807bf617318" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_9e325f82-576d-4181-820d-8f66d1fec233" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_AmendmentFlag_9e325f82-576d-4181-820d-8f66d1fec233" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_0dfa2071-e4b7-42bf-b723-a5ef9b7a61fa" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityIncorporationStateCountryCode_0dfa2071-e4b7-42bf-b723-a5ef9b7a61fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_5be4853b-8b8c-4ce2-b23b-c861bd31cadb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityFileNumber_5be4853b-8b8c-4ce2-b23b-c861bd31cadb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_89c6c1c4-85f2-4e2b-9b4d-31e458564046" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityTaxIdentificationNumber_89c6c1c4-85f2-4e2b-9b4d-31e458564046" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_51cd8960-c5a9-4a0e-b64c-17aa57f4f39c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityAddressAddressLine1_51cd8960-c5a9-4a0e-b64c-17aa57f4f39c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_856246b4-d651-4437-b994-7503d9b0083d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityAddressAddressLine2_856246b4-d651-4437-b994-7503d9b0083d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_72575ac2-7b81-4127-ac2c-12535444662f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityAddressCityOrTown_72575ac2-7b81-4127-ac2c-12535444662f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_f924475c-8ca4-470c-8374-d038de793562" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityAddressStateOrProvince_f924475c-8ca4-470c-8374-d038de793562" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_67d9385a-5a2b-4ecb-8e6c-9f80475a252a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityAddressPostalZipCode_67d9385a-5a2b-4ecb-8e6c-9f80475a252a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_d2119519-5e9c-4239-b899-5d62a35eed7b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_CityAreaCode_d2119519-5e9c-4239-b899-5d62a35eed7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_70caf649-93e3-4977-9534-9bcb3043c8a3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_LocalPhoneNumber_70caf649-93e3-4977-9534-9bcb3043c8a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_b2ed2317-c1a4-4429-9ebd-a1bbde340d02" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_WrittenCommunications_b2ed2317-c1a4-4429-9ebd-a1bbde340d02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_921ad7b4-1e82-4e91-b98d-1533581b2794" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_SolicitingMaterial_921ad7b4-1e82-4e91-b98d-1533581b2794" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_046fc800-5663-4a07-93bb-b06caedcea38" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_PreCommencementTenderOffer_046fc800-5663-4a07-93bb-b06caedcea38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_8c20d204-e426-420b-aa9c-3c2f80baa6b2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_8c20d204-e426-420b-aa9c-3c2f80baa6b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_659f0e11-713b-4e66-9092-091c22f0429a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_Security12bTitle_659f0e11-713b-4e66-9092-091c22f0429a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_6490c61e-9ff3-46be-ad7c-dae89c693a54" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_TradingSymbol_6490c61e-9ff3-46be-ad7c-dae89c693a54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_1c3f302f-660f-426f-9721-50fc74a9a408" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6ee14222-d141-412c-ba49-a4de3e3bbf0e" xlink:to="loc_dei_EntityEmergingGrowthCompany_1c3f302f-660f-426f-9721-50fc74a9a408" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
