<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:84ec410f-3815-4763-9bc2-b77d68e36727,g:546a3c6e-3b19-4bdc-9aac-42f0e40439c5-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/Cover" xlink:type="simple" xlink:href="sibn-20201231.xsd#Cover"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/Cover" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="sibn-20201231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_6999145d-e327-4aa6-8a02-1b224c4257be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_ec6a7f7c-d8cd-42dc-b0f1-117db39d948a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_6999145d-e327-4aa6-8a02-1b224c4257be" xlink:to="loc_us-gaap_AccountsPayableCurrent_ec6a7f7c-d8cd-42dc-b0f1-117db39d948a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_f969f1a0-ec58-4ac3-933b-5e49ffdc47be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_6999145d-e327-4aa6-8a02-1b224c4257be" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_f969f1a0-ec58-4ac3-933b-5e49ffdc47be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_9a57054c-a416-4b93-b93d-3e0003cfcf22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_6999145d-e327-4aa6-8a02-1b224c4257be" xlink:to="loc_us-gaap_LongTermDebtCurrent_9a57054c-a416-4b93-b93d-3e0003cfcf22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_a6711f62-0073-4a70-9b65-009a32c912c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_a7c616e6-7d7f-45f3-bc10-ab2233cae82e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a6711f62-0073-4a70-9b65-009a32c912c9" xlink:to="loc_us-gaap_PreferredStockValue_a7c616e6-7d7f-45f3-bc10-ab2233cae82e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_863bf3ba-e297-4d92-9001-e28fdf736d3c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a6711f62-0073-4a70-9b65-009a32c912c9" xlink:to="loc_us-gaap_CommonStockValue_863bf3ba-e297-4d92-9001-e28fdf736d3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_873bb53a-4400-4b87-8e40-df941f848d7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a6711f62-0073-4a70-9b65-009a32c912c9" xlink:to="loc_us-gaap_AdditionalPaidInCapital_873bb53a-4400-4b87-8e40-df941f848d7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ca77f768-cf42-43b0-b82d-809648662eee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a6711f62-0073-4a70-9b65-009a32c912c9" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ca77f768-cf42-43b0-b82d-809648662eee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_72f7af6d-6a2d-4602-a5df-dbfb934f4320" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a6711f62-0073-4a70-9b65-009a32c912c9" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_72f7af6d-6a2d-4602-a5df-dbfb934f4320" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_b197df75-d9ff-4ccf-aed8-bfa0d78949df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_6137d981-8886-4056-8bc6-46857126d9c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b197df75-d9ff-4ccf-aed8-bfa0d78949df" xlink:to="loc_us-gaap_Liabilities_6137d981-8886-4056-8bc6-46857126d9c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_9ab9043a-ebe1-448c-b928-5c58cc84fd75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b197df75-d9ff-4ccf-aed8-bfa0d78949df" xlink:to="loc_us-gaap_CommitmentsAndContingencies_9ab9043a-ebe1-448c-b928-5c58cc84fd75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1d8563e2-3dde-4fa3-99e3-86eba1ab6003" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b197df75-d9ff-4ccf-aed8-bfa0d78949df" xlink:to="loc_us-gaap_StockholdersEquity_1d8563e2-3dde-4fa3-99e3-86eba1ab6003" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_a2563f4c-e59f-46a7-8d75-72a061c9de3d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c4ed123f-25c5-4657-a9f5-9755335d5407" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a2563f4c-e59f-46a7-8d75-72a061c9de3d" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c4ed123f-25c5-4657-a9f5-9755335d5407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_2c5345f5-d580-49e9-8f82-15346868d064" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a2563f4c-e59f-46a7-8d75-72a061c9de3d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_2c5345f5-d580-49e9-8f82-15346868d064" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_e71afad4-5980-4e2e-815c-6823213584a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a2563f4c-e59f-46a7-8d75-72a061c9de3d" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_e71afad4-5980-4e2e-815c-6823213584a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_b70ec34a-8de1-40ca-999f-9b698aa09a62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a2563f4c-e59f-46a7-8d75-72a061c9de3d" xlink:to="loc_us-gaap_InventoryNet_b70ec34a-8de1-40ca-999f-9b698aa09a62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a03bad10-7b3b-4a0d-8288-22e1195631b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a2563f4c-e59f-46a7-8d75-72a061c9de3d" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a03bad10-7b3b-4a0d-8288-22e1195631b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_6ca8298f-2e3d-4d54-9327-012a2fbef9f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_11084c9f-1acd-4c79-bb64-2e7c7bf6f4a1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6ca8298f-2e3d-4d54-9327-012a2fbef9f6" xlink:to="loc_us-gaap_AssetsCurrent_11084c9f-1acd-4c79-bb64-2e7c7bf6f4a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_3be21383-6967-424f-88e7-958fe64c4a10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6ca8298f-2e3d-4d54-9327-012a2fbef9f6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_3be21383-6967-424f-88e7-958fe64c4a10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_809ff84e-cf4e-49cf-8231-f176b6c652c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6ca8298f-2e3d-4d54-9327-012a2fbef9f6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_809ff84e-cf4e-49cf-8231-f176b6c652c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_087754ba-80c1-47fe-8594-ffbd8ef9b7e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6ca8298f-2e3d-4d54-9327-012a2fbef9f6" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_087754ba-80c1-47fe-8594-ffbd8ef9b7e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_7ca0b940-2e8b-4db2-8608-fc85c4143bb7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_a7908b76-7753-4d04-bcf1-112a10711bd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_7ca0b940-2e8b-4db2-8608-fc85c4143bb7" xlink:to="loc_us-gaap_LiabilitiesCurrent_a7908b76-7753-4d04-bcf1-112a10711bd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_5017d822-1e61-4140-aacf-8b74528421fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_7ca0b940-2e8b-4db2-8608-fc85c4143bb7" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_5017d822-1e61-4140-aacf-8b74528421fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_89086d0c-1f6f-48a8-abe9-92301ffe9e33" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_7ca0b940-2e8b-4db2-8608-fc85c4143bb7" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_89086d0c-1f6f-48a8-abe9-92301ffe9e33" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="sibn-20201231.xsd#CONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="sibn-20201231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_b6bd9686-1d8d-42d4-ac67-9db4cf80db4b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c79ff0ac-326b-40d7-ba94-2fb8ab5dd547" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_b6bd9686-1d8d-42d4-ac67-9db4cf80db4b" xlink:to="loc_us-gaap_NetIncomeLoss_c79ff0ac-326b-40d7-ba94-2fb8ab5dd547" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_64bc6b15-86b6-4a84-ab01-4382c33eb6d6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_b6bd9686-1d8d-42d4-ac67-9db4cf80db4b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_64bc6b15-86b6-4a84-ab01-4382c33eb6d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_555ab1d1-3734-4f3c-8f11-a7b699b46042" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_b6bd9686-1d8d-42d4-ac67-9db4cf80db4b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_555ab1d1-3734-4f3c-8f11-a7b699b46042" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_6f2aa962-040b-4f40-9765-fb252bda1b4c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_6ce585cf-34d1-42f8-8ff1-ce75972847c3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_6f2aa962-040b-4f40-9765-fb252bda1b4c" xlink:to="loc_us-gaap_SellingAndMarketingExpense_6ce585cf-34d1-42f8-8ff1-ce75972847c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_e39446d7-0611-4a19-b46b-78cea9fdd61e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_6f2aa962-040b-4f40-9765-fb252bda1b4c" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_e39446d7-0611-4a19-b46b-78cea9fdd61e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_d6c54cfa-7e56-459f-a807-18f0d18bb501" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_6f2aa962-040b-4f40-9765-fb252bda1b4c" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_d6c54cfa-7e56-459f-a807-18f0d18bb501" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_c71025f8-4bc7-496a-a339-78d7c5ee11d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b086ded7-7122-459f-8a37-b9bcc642bd66" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_c71025f8-4bc7-496a-a339-78d7c5ee11d9" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b086ded7-7122-459f-8a37-b9bcc642bd66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_fcb6277f-652c-4357-a067-7f1b34852deb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_c71025f8-4bc7-496a-a339-78d7c5ee11d9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_fcb6277f-652c-4357-a067-7f1b34852deb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_fa2f819b-fa43-4d91-ab67-acc0c1c3dba9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_fb7e881c-0262-464a-a3df-be21b3a2d120" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_fa2f819b-fa43-4d91-ab67-acc0c1c3dba9" xlink:to="loc_us-gaap_GrossProfit_fb7e881c-0262-464a-a3df-be21b3a2d120" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_04047258-c309-4c78-8518-3a54d4443045" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_fa2f819b-fa43-4d91-ab67-acc0c1c3dba9" xlink:to="loc_us-gaap_OperatingExpenses_04047258-c309-4c78-8518-3a54d4443045" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_7cacd5bf-249c-46a3-8e23-11ec374085e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_adf4d85e-450b-44bb-bfe8-76d531f023dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_7cacd5bf-249c-46a3-8e23-11ec374085e7" xlink:to="loc_us-gaap_OperatingIncomeLoss_adf4d85e-450b-44bb-bfe8-76d531f023dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_82299700-34a5-40ca-91d9-61e1b3dbb901" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_7cacd5bf-249c-46a3-8e23-11ec374085e7" xlink:to="loc_us-gaap_InvestmentIncomeInterest_82299700-34a5-40ca-91d9-61e1b3dbb901" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_76e9ae7e-8aa9-47bf-98c6-b57e6266d48e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_7cacd5bf-249c-46a3-8e23-11ec374085e7" xlink:to="loc_us-gaap_InterestExpense_76e9ae7e-8aa9-47bf-98c6-b57e6266d48e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_173a7ab6-7ed8-4f3a-8c8e-fbe3fa439c6a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_7cacd5bf-249c-46a3-8e23-11ec374085e7" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_173a7ab6-7ed8-4f3a-8c8e-fbe3fa439c6a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="sibn-20201231.xsd#CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="sibn-20201231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_511d2724-c18c-4bbf-b494-004b4877395f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_ProceedsFromMaturityOfMarketableSecurities_b68e4d21-844f-4a02-99d1-5cc93735d131" xlink:href="sibn-20201231.xsd#sibn_ProceedsFromMaturityOfMarketableSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_511d2724-c18c-4bbf-b494-004b4877395f" xlink:to="loc_sibn_ProceedsFromMaturityOfMarketableSecurities_b68e4d21-844f-4a02-99d1-5cc93735d131" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_ProceedsFromSaleOfMarketableSecurities_92da616c-9fa1-4ab5-a3f8-e61167ac6e52" xlink:href="sibn-20201231.xsd#sibn_ProceedsFromSaleOfMarketableSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_511d2724-c18c-4bbf-b494-004b4877395f" xlink:to="loc_sibn_ProceedsFromSaleOfMarketableSecurities_92da616c-9fa1-4ab5-a3f8-e61167ac6e52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_4fd483b1-b31a-483c-a74f-d5cd2172639b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_511d2724-c18c-4bbf-b494-004b4877395f" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_4fd483b1-b31a-483c-a74f-d5cd2172639b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_18aa2f9e-4afa-44c2-83eb-baafc9fa1f5b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_511d2724-c18c-4bbf-b494-004b4877395f" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_18aa2f9e-4afa-44c2-83eb-baafc9fa1f5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1a3865f4-889c-422c-9a4f-27e4eaeb2428" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_NetIncomeLoss_1a3865f4-889c-422c-9a4f-27e4eaeb2428" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_3e2f09c3-0d83-4753-b68a-2cc91d407c54" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_ShareBasedCompensation_3e2f09c3-0d83-4753-b68a-2cc91d407c54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_bfa25bcf-45b0-477f-bca5-5c359fa227aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_bfa25bcf-45b0-477f-bca5-5c359fa227aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_7216b5cb-2719-4855-ade4-443cf3bcacb1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_7216b5cb-2719-4855-ade4-443cf3bcacb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_2f757e0c-1cc0-407b-a8ad-3f270a9fdc69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_2f757e0c-1cc0-407b-a8ad-3f270a9fdc69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_d775fcc2-64c5-42d1-ab9a-2d6aec6e0250" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MarketableSecuritiesRealizedGainLoss"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_MarketableSecuritiesRealizedGainLoss_d775fcc2-64c5-42d1-ab9a-2d6aec6e0250" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_8fd47317-4f0b-4f78-a828-f69092b65126" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_8fd47317-4f0b-4f78-a828-f69092b65126" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_2cc2c1bb-6f5b-400d-b2d3-165ed95a49ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_2cc2c1bb-6f5b-400d-b2d3-165ed95a49ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_f6a18fab-e08e-445b-ae43-9e599436f861" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_f6a18fab-e08e-445b-ae43-9e599436f861" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f57de2ab-a93d-4fb4-aa99-34034f45d3c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f57de2ab-a93d-4fb4-aa99-34034f45d3c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_f35ab2e2-2013-4990-bb99-b8a9992267cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_f35ab2e2-2013-4990-bb99-b8a9992267cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c895492a-3775-48ed-8828-70139cc2011d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c895492a-3775-48ed-8828-70139cc2011d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_ae25428f-c8eb-454c-8ea2-497fbd751144" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_ae25428f-c8eb-454c-8ea2-497fbd751144" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_999bcd9f-2661-4374-ac9a-f266454d381b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f6fd3582-f247-4b77-a66f-b98e61801944" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_999bcd9f-2661-4374-ac9a-f266454d381b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_d38af786-4e41-40c3-8d52-8d2235d07b59" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_d38af786-4e41-40c3-8d52-8d2235d07b59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_96376ab0-5c72-4265-8070-b67a18b21e3e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_96376ab0-5c72-4265-8070-b67a18b21e3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_447c6e8f-ec32-4667-8a98-eec6eeab1237" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_447c6e8f-ec32-4667-8a98-eec6eeab1237" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_7c4b2d96-607b-4126-a111-02b8b2ceae77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_7c4b2d96-607b-4126-a111-02b8b2ceae77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_5ce936f1-bc73-4bdb-b279-b6acd5a37cb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_5ce936f1-bc73-4bdb-b279-b6acd5a37cb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_4752cee8-726f-4b18-b502-0b0e912d228f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_4752cee8-726f-4b18-b502-0b0e912d228f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_d28a1dd7-2da1-48ee-9ed6-b56e6f720673" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_ProceedsFromStockPlans_d28a1dd7-2da1-48ee-9ed6-b56e6f720673" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_PaymentsForRepurchaseOfUnvestedEarlyExercisedStockOptions_df8978e8-16fa-4ae4-b5ae-3a678c4806f5" xlink:href="sibn-20201231.xsd#sibn_PaymentsForRepurchaseOfUnvestedEarlyExercisedStockOptions"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_sibn_PaymentsForRepurchaseOfUnvestedEarlyExercisedStockOptions_df8978e8-16fa-4ae4-b5ae-3a678c4806f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_f8d0c695-5865-4be4-a6b4-3ce6213a891d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f9f51ff5-5f17-43e4-9cd2-1c24f6427f85" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_f8d0c695-5865-4be4-a6b4-3ce6213a891d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8f6d3ce8-457c-4d3d-b4dc-bdd470063129" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5b198db0-ce09-40f4-82db-ade60c370496" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8f6d3ce8-457c-4d3d-b4dc-bdd470063129" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5b198db0-ce09-40f4-82db-ade60c370496" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d0ead6b7-e26b-4f4e-be93-ff11d431e295" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8f6d3ce8-457c-4d3d-b4dc-bdd470063129" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d0ead6b7-e26b-4f4e-be93-ff11d431e295" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c1c4701b-81a5-4290-97cf-c398ff3c6393" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8f6d3ce8-457c-4d3d-b4dc-bdd470063129" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c1c4701b-81a5-4290-97cf-c398ff3c6393" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0e99a24d-ff09-4e67-8398-006bab6d53d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8f6d3ce8-457c-4d3d-b4dc-bdd470063129" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0e99a24d-ff09-4e67-8398-006bab6d53d9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/TheCompanyandNatureofBusiness" xlink:type="simple" xlink:href="sibn-20201231.xsd#TheCompanyandNatureofBusiness"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/TheCompanyandNatureofBusiness" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/TheCompanyandNatureofBusinessDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#TheCompanyandNatureofBusinessDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/TheCompanyandNatureofBusinessDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesSegmentsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesSegmentsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesSegmentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesLiquidityDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesLiquidityDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesLiquidityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesImpairmentofLongLivedAssetsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesImpairmentofLongLivedAssetsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesImpairmentofLongLivedAssetsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesRevenueRecognitionDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesRevenueRecognitionDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesRevenueRecognitionDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesWarrantyProgramDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesWarrantyProgramDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesWarrantyProgramDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesAdvertisingExpendituresDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#SummaryofSignificantAccountingPoliciesAdvertisingExpendituresDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/SummaryofSignificantAccountingPoliciesAdvertisingExpendituresDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/MarketableSecurities" xlink:type="simple" xlink:href="sibn-20201231.xsd#MarketableSecurities"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/MarketableSecurities" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/MarketableSecuritiesTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#MarketableSecuritiesTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/MarketableSecuritiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/MarketableSecuritiesDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#MarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/MarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis_7c754d20-dd75-4882-85c4-9cf87ccd2718" xlink:href="sibn-20201231.xsd#sibn_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax_6d5426a1-3c55-4128-b77c-b77da3937cd5" xlink:href="sibn-20201231.xsd#sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis_7c754d20-dd75-4882-85c4-9cf87ccd2718" xlink:to="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax_6d5426a1-3c55-4128-b77c-b77da3937cd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax_0064b3a9-4819-4afa-801f-10ae80bcd14b" xlink:href="sibn-20201231.xsd#sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis_7c754d20-dd75-4882-85c4-9cf87ccd2718" xlink:to="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax_0064b3a9-4819-4afa-801f-10ae80bcd14b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_7dad8efe-8e62-4e65-9ebe-22305a71f073" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis_7c754d20-dd75-4882-85c4-9cf87ccd2718" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_7dad8efe-8e62-4e65-9ebe-22305a71f073" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAmortizedCostBasis_49f354cc-46cf-403f-88e7-a551b90e6816" xlink:href="sibn-20201231.xsd#sibn_AvailableForSaleDebtSecuritiesNoncurrentAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedGainBeforeTax_0cf03466-bde0-4347-bed6-88a3738832e8" xlink:href="sibn-20201231.xsd#sibn_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAmortizedCostBasis_49f354cc-46cf-403f-88e7-a551b90e6816" xlink:to="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedGainBeforeTax_0cf03466-bde0-4347-bed6-88a3738832e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedLossBeforeTax_855f52d6-14fa-4354-99b6-dae299c8d27c" xlink:href="sibn-20201231.xsd#sibn_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAmortizedCostBasis_49f354cc-46cf-403f-88e7-a551b90e6816" xlink:to="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedLossBeforeTax_855f52d6-14fa-4354-99b6-dae299c8d27c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_f79131ed-c99b-4878-bb95-0a9f0a7158a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_AvailableForSaleDebtSecuritiesNoncurrentAmortizedCostBasis_49f354cc-46cf-403f-88e7-a551b90e6816" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_f79131ed-c99b-4878-bb95-0a9f0a7158a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_MarketableSecuritiesAmortizedCost_fbe5b26a-599c-42e8-8671-61f03ee95ac0" xlink:href="sibn-20201231.xsd#sibn_MarketableSecuritiesAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_MarketableSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_fce87e4d-9c07-49e7-8a2a-66559aa01da4" xlink:href="sibn-20201231.xsd#sibn_MarketableSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_fbe5b26a-599c-42e8-8671-61f03ee95ac0" xlink:to="loc_sibn_MarketableSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_fce87e4d-9c07-49e7-8a2a-66559aa01da4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_MarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_688a26c5-9240-4221-ad06-4fb7b7c91c53" xlink:href="sibn-20201231.xsd#sibn_MarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_fbe5b26a-599c-42e8-8671-61f03ee95ac0" xlink:to="loc_sibn_MarketableSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_688a26c5-9240-4221-ad06-4fb7b7c91c53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_MarketableSecuritiesFairValue_462059ea-02c7-4def-89d9-106c52b1f1da" xlink:href="sibn-20201231.xsd#sibn_MarketableSecuritiesFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_fbe5b26a-599c-42e8-8671-61f03ee95ac0" xlink:to="loc_sibn_MarketableSecuritiesFairValue_462059ea-02c7-4def-89d9-106c52b1f1da" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="sibn-20201231.xsd#FairValueMeasurement"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/FairValueMeasurement" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#FairValueMeasurementTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/FairValueMeasurementTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/FairValueMeasurementMarketableSecuritiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#FairValueMeasurementMarketableSecuritiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/FairValueMeasurementMarketableSecuritiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponents" xlink:type="simple" xlink:href="sibn-20201231.xsd#BalanceSheetComponents"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponents" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#BalanceSheetComponentsTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#BalanceSheetComponentsPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_0ca9d5f5-cc6f-4d2b-925f-ce08b60798f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_856811f2-1d83-4932-9849-f95682fd9b59" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_0ca9d5f5-cc6f-4d2b-925f-ce08b60798f2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_856811f2-1d83-4932-9849-f95682fd9b59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_41057ff4-7744-456d-a883-2a49d503ad91" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_0ca9d5f5-cc6f-4d2b-925f-ce08b60798f2" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_41057ff4-7744-456d-a883-2a49d503ad91" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsAccruedLiabilitiesandOtherDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#BalanceSheetComponentsAccruedLiabilitiesandOtherDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsAccruedLiabilitiesandOtherDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_0343796e-ade2-4764-9f41-f3e8733d47be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_34c68465-69ec-490b-afa4-c3355452e732" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0343796e-ade2-4764-9f41-f3e8733d47be" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_34c68465-69ec-490b-afa4-c3355452e732" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_7f2792e2-0029-46cb-8e36-6e89712dd90d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0343796e-ade2-4764-9f41-f3e8733d47be" xlink:to="loc_us-gaap_LitigationReserveCurrent_7f2792e2-0029-46cb-8e36-6e89712dd90d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_97e03d28-0a93-4872-bd11-2842573314b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0343796e-ade2-4764-9f41-f3e8733d47be" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_97e03d28-0a93-4872-bd11-2842573314b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_79bae5b1-29ea-48ae-a83d-deb5db5f0cfc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0343796e-ade2-4764-9f41-f3e8733d47be" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_79bae5b1-29ea-48ae-a83d-deb5db5f0cfc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="sibn-20201231.xsd#CommitmentsandContingencies"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingencies" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#CommitmentsandContingenciesTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_36c4ba54-aa12-47fd-bd20-b5a8075ee230" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_36c4ba54-aa12-47fd-bd20-b5a8075ee230" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_bf68b7a2-8afa-40b5-aa93-47452588fd2a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_bf68b7a2-8afa-40b5-aa93-47452588fd2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3fe5cba7-c719-49da-83b9-c34636c9dceb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3fe5cba7-c719-49da-83b9-c34636c9dceb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_0f1f6d7e-74aa-40e7-b219-3fd0511e4d4f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_0f1f6d7e-74aa-40e7-b219-3fd0511e4d4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_7bfd1641-ea4b-421f-8ccc-c73828bde5a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_7bfd1641-ea4b-421f-8ccc-c73828bde5a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_f4249564-19e6-4554-95d0-c75e7437cc73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ad1a168b-371c-47ea-825d-ab68f2386106" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_f4249564-19e6-4554-95d0-c75e7437cc73" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/Borrowings" xlink:type="simple" xlink:href="sibn-20201231.xsd#Borrowings"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/Borrowings" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#BorrowingsTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#BorrowingsSummaryofBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_b95b2a6a-9ff7-4ec3-aeae-4c3aa8e4704d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_c7fb18af-8630-4402-8451-38812a273415" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_b95b2a6a-9ff7-4ec3-aeae-4c3aa8e4704d" xlink:to="loc_us-gaap_LongTermDebtCurrent_c7fb18af-8630-4402-8451-38812a273415" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_48330508-9c3f-4c01-9f95-382bca28a19c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_b95b2a6a-9ff7-4ec3-aeae-4c3aa8e4704d" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_48330508-9c3f-4c01-9f95-382bca28a19c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails_1" xlink:type="simple" xlink:href="sibn-20201231.xsd#BorrowingsSummaryofBorrowingsDetails_1"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_4c29bb1c-50c0-4f49-8aed-5377b5ed4ae2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_2ddbf566-33e9-4b3d-8488-b3149051cd56" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_4c29bb1c-50c0-4f49-8aed-5377b5ed4ae2" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_2ddbf566-33e9-4b3d-8488-b3149051cd56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_39970a9e-b656-48ef-87a8-f0bdaff67ac8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_4c29bb1c-50c0-4f49-8aed-5377b5ed4ae2" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_39970a9e-b656-48ef-87a8-f0bdaff67ac8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFeeAmount_e0ce9403-6b02-432c-809b-6e65d270e85e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFeeAmount"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_4c29bb1c-50c0-4f49-8aed-5377b5ed4ae2" xlink:to="loc_us-gaap_DebtInstrumentFeeAmount_e0ce9403-6b02-432c-809b-6e65d270e85e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsNarrativeDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#BorrowingsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsAnnualFutureMinimumPrincipalPaymentsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#BorrowingsAnnualFutureMinimumPrincipalPaymentsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsAnnualFutureMinimumPrincipalPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_a23c5740-16dd-4439-af94-db4b7d102064" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_ad40aa65-0e92-46a9-88b1-8b88958af042" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_a23c5740-16dd-4439-af94-db4b7d102064" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_ad40aa65-0e92-46a9-88b1-8b88958af042" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_54d6a4e3-7ddb-4ed3-9511-813a35f29274" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_a23c5740-16dd-4439-af94-db4b7d102064" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_54d6a4e3-7ddb-4ed3-9511-813a35f29274" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_451e7018-3c15-4f6c-8060-bbe2f1f13874" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_a23c5740-16dd-4439-af94-db4b7d102064" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_451e7018-3c15-4f6c-8060-bbe2f1f13874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_9c63454d-48a8-4c8e-bdc3-8981c4aa3761" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_a23c5740-16dd-4439-af94-db4b7d102064" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_9c63454d-48a8-4c8e-bdc3-8981c4aa3761" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_b7fec926-3648-4365-9e3c-f0ea54537e66" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_a23c5740-16dd-4439-af94-db4b7d102064" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_b7fec926-3648-4365-9e3c-f0ea54537e66" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/Warrants" xlink:type="simple" xlink:href="sibn-20201231.xsd#Warrants"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/Warrants" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/WarrantsTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#WarrantsTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/WarrantsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/WarrantsIssuedandOutstandingDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#WarrantsIssuedandOutstandingDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/WarrantsIssuedandOutstandingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CommonandPreferredStock" xlink:type="simple" xlink:href="sibn-20201231.xsd#CommonandPreferredStock"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommonandPreferredStock" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/CommonandPreferredStockNarrativeDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#CommonandPreferredStockNarrativeDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommonandPreferredStockNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensation"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationStockOptionActivityDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationStockOptionActivityDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationStockOptionActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationOutstandingOptionsandExercisableOptionsInformationbyRangeofExercisePricesDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationOutstandingOptionsandExercisableOptionsInformationbyRangeofExercisePricesDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationOutstandingOptionsandExercisableOptionsInformationbyRangeofExercisePricesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationValuationAssumptionsforStockOptionsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationValuationAssumptionsforStockOptionsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationValuationAssumptionsforStockOptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationRestrictedStockUnitActivityDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationRestrictedStockUnitActivityDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationRestrictedStockUnitActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationValuationAssumptionsforESPPPurchaseRightsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationValuationAssumptionsforESPPPurchaseRightsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationValuationAssumptionsforESPPPurchaseRightsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#StockBasedCompensationStockBasedCompensationExpenseDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/EmployeeBenefitPlan" xlink:type="simple" xlink:href="sibn-20201231.xsd#EmployeeBenefitPlan"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/EmployeeBenefitPlan" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/EmployeeBenefitPlanDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#EmployeeBenefitPlanDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/EmployeeBenefitPlanDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/NetLossPerShareofCommonStock" xlink:type="simple" xlink:href="sibn-20201231.xsd#NetLossPerShareofCommonStock"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/NetLossPerShareofCommonStock" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/NetLossPerShareofCommonStockTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#NetLossPerShareofCommonStockTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/NetLossPerShareofCommonStockTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/NetLossPerShareofCommonStockScheduleofEarningsPerShareDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#NetLossPerShareofCommonStockScheduleofEarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/NetLossPerShareofCommonStockScheduleofEarningsPerShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/NetLossPerShareofCommonStockAntidilutiveSecuritiesExcludingfromComputationofEarningsPerShareDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#NetLossPerShareofCommonStockAntidilutiveSecuritiesExcludingfromComputationofEarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/NetLossPerShareofCommonStockAntidilutiveSecuritiesExcludingfromComputationofEarningsPerShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxes" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxes"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxes" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesTables"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesComponentsofLossBeforeIncomeTaxesDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesComponentsofLossBeforeIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesComponentsofLossBeforeIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_64ec3cbe-fbc2-491f-9f73-2a33002b1aa4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_ee1f99ce-4213-43d7-a6c1-4c6095da53c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_64ec3cbe-fbc2-491f-9f73-2a33002b1aa4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_ee1f99ce-4213-43d7-a6c1-4c6095da53c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_dfae980d-1fa2-4eba-85dc-940526802876" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_64ec3cbe-fbc2-491f-9f73-2a33002b1aa4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_dfae980d-1fa2-4eba-85dc-940526802876" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesComponentsofDeferredIncomeTaxesDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesComponentsofDeferredIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesComponentsofDeferredIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_sibn_DeferredIncomeTaxExpenseBenefitNetOfValuationAllowance_858e5c17-871e-4c3d-a466-9a13dcbf31a2" xlink:href="sibn-20201231.xsd#sibn_DeferredIncomeTaxExpenseBenefitNetOfValuationAllowance"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_380415a1-73d8-476c-ad72-8a6e4d5125ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_DeferredIncomeTaxExpenseBenefitNetOfValuationAllowance_858e5c17-871e-4c3d-a466-9a13dcbf31a2" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_380415a1-73d8-476c-ad72-8a6e4d5125ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_f01a7a85-1b2d-4dd2-a8f0-6372d715979a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_DeferredIncomeTaxExpenseBenefitNetOfValuationAllowance_858e5c17-871e-4c3d-a466-9a13dcbf31a2" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_f01a7a85-1b2d-4dd2-a8f0-6372d715979a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_b9ff26a2-cbe6-47b8-994a-5f4338dea0a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_812fef9e-c177-4f6a-8968-50d7e9ccf708" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_b9ff26a2-cbe6-47b8-994a-5f4338dea0a4" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_812fef9e-c177-4f6a-8968-50d7e9ccf708" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_c4fe6351-a14c-4539-b255-825399175d09" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_b9ff26a2-cbe6-47b8-994a-5f4338dea0a4" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_c4fe6351-a14c-4539-b255-825399175d09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_10a7345c-7f42-400b-a440-3b450eeaaf5f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_b9ff26a2-cbe6-47b8-994a-5f4338dea0a4" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_10a7345c-7f42-400b-a440-3b450eeaaf5f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesReconciliationofEffectiveIncomeTaxRateDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesReconciliationofEffectiveIncomeTaxRateDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesReconciliationofEffectiveIncomeTaxRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_cbf77f74-38e4-4c09-b1ff-1d5ef1dc0bbe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_cbf77f74-38e4-4c09-b1ff-1d5ef1dc0bbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_d490c3dd-8643-47b4-a174-e3bfbfad79b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_d490c3dd-8643-47b4-a174-e3bfbfad79b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_61860a45-285c-4ace-9791-e8f8230f39b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_61860a45-285c-4ace-9791-e8f8230f39b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_fe5d0062-190e-4a50-965c-22c1e2bac4c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_fe5d0062-190e-4a50-965c-22c1e2bac4c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitPercent_8f7228f6-b651-4c27-acb5-d86edec03935" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitPercent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitPercent_8f7228f6-b651-4c27-acb5-d86edec03935" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_6d4a43b9-90d9-4253-b73b-e7c6dc45b8f1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_6d4a43b9-90d9-4253-b73b-e7c6dc45b8f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_0badb4e0-a749-4933-aca8-9b52b6c12847" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_44067d3e-fb12-4121-b2f0-d349b5db6156" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_0badb4e0-a749-4933-aca8-9b52b6c12847" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesTemporaryDifferencesandCarryforwardsandDeferredTaxAssetsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesTemporaryDifferencesandCarryforwardsandDeferredTaxAssetsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesTemporaryDifferencesandCarryforwardsandDeferredTaxAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_3c350852-b7c3-462f-92f2-d3f2c09c1dc8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_f1370d6a-dd72-405e-9fdb-af8df38eb48e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_3c350852-b7c3-462f-92f2-d3f2c09c1dc8" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_f1370d6a-dd72-405e-9fdb-af8df38eb48e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_c373903a-2c6c-48f1-a422-6cfece49e258" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_3c350852-b7c3-462f-92f2-d3f2c09c1dc8" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_c373903a-2c6c-48f1-a422-6cfece49e258" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_c9aca0b8-7186-49b4-b056-567906711370" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_aa8cc6c5-bc0e-4a49-bb4b-3a1d8f8f20ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_c9aca0b8-7186-49b4-b056-567906711370" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_aa8cc6c5-bc0e-4a49-bb4b-3a1d8f8f20ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_201afe58-1150-463d-8ed1-a18e631af8f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_c9aca0b8-7186-49b4-b056-567906711370" xlink:to="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_201afe58-1150-463d-8ed1-a18e631af8f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_eea6eb2d-8b19-4028-9c3b-074575e77929" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_c9aca0b8-7186-49b4-b056-567906711370" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_eea6eb2d-8b19-4028-9c3b-074575e77929" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_1d22dd34-2892-4a60-a7f0-9db645548895" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_c9aca0b8-7186-49b4-b056-567906711370" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_1d22dd34-2892-4a60-a7f0-9db645548895" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_DeferredTaxAssetsDepreciationAndAmortization_e73a2567-27af-4996-802f-71672f54c2db" xlink:href="sibn-20201231.xsd#sibn_DeferredTaxAssetsDepreciationAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_c9aca0b8-7186-49b4-b056-567906711370" xlink:to="loc_sibn_DeferredTaxAssetsDepreciationAndAmortization_e73a2567-27af-4996-802f-71672f54c2db" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesChangesinValuationAllowanceDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesChangesinValuationAllowanceDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesChangesinValuationAllowanceDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/IncomeTaxesUncertainIncomeTaxPositionsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#IncomeTaxesUncertainIncomeTaxPositionsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/IncomeTaxesUncertainIncomeTaxPositionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/RelatedPartyTransactions" xlink:type="simple" xlink:href="sibn-20201231.xsd#RelatedPartyTransactions"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/RelatedPartyTransactions" xlink:type="extended"/>
  <link:roleRef roleURI="http://si-bone.com/role/RelatedPartyTransactionsDetails" xlink:type="simple" xlink:href="sibn-20201231.xsd#RelatedPartyTransactionsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/RelatedPartyTransactionsDetails" xlink:type="extended"/>
</link:linkbase>
