<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:9f74a0e6-64b6-4c8a-a88c-6650d567d62e,g:0f4f29c4-0e2e-4c5e-b213-89cc089b64f3-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/Cover" xlink:type="simple" xlink:href="sibn-20210610.xsd#Cover"/>
  <link:presentationLink xlink:role="http://si-bone.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_9bf96286-1fb1-46db-94fa-ee7b15ddb143" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_DocumentType_9bf96286-1fb1-46db-94fa-ee7b15ddb143" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_85e56c60-0de1-4bce-8c90-f52c2f1f2915" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_DocumentPeriodEndDate_85e56c60-0de1-4bce-8c90-f52c2f1f2915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_ca2d5479-894b-4ad7-a204-f33fdc4fc231" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityRegistrantName_ca2d5479-894b-4ad7-a204-f33fdc4fc231" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_3e09e9ad-99e4-45e5-a97a-c422fd37235f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityCentralIndexKey_3e09e9ad-99e4-45e5-a97a-c422fd37235f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_150ae4ac-c3e1-45b8-a4a0-76f839aa4418" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_AmendmentFlag_150ae4ac-c3e1-45b8-a4a0-76f839aa4418" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_cb40e7a5-b6dd-4914-b0b4-ce3a942fab7b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityIncorporationStateCountryCode_cb40e7a5-b6dd-4914-b0b4-ce3a942fab7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_9e89c860-b8a4-422a-b12e-38391689e9a9" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityFileNumber_9e89c860-b8a4-422a-b12e-38391689e9a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_f4082fda-da1f-450d-b752-b93318aa8594" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityTaxIdentificationNumber_f4082fda-da1f-450d-b752-b93318aa8594" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_018bd3b4-c3f1-48a1-83c2-3c5c3f85c7a8" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityAddressAddressLine1_018bd3b4-c3f1-48a1-83c2-3c5c3f85c7a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_58d3cf9b-8593-41ab-9eb2-151b8f2a8800" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityAddressAddressLine2_58d3cf9b-8593-41ab-9eb2-151b8f2a8800" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_c8c3ea19-56f1-41a6-89de-aaf4753667c4" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityAddressCityOrTown_c8c3ea19-56f1-41a6-89de-aaf4753667c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_54be80d4-1edb-4009-af37-6bac08871ba8" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityAddressStateOrProvince_54be80d4-1edb-4009-af37-6bac08871ba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_2dae2c23-5e1c-4655-8a12-10b46a8fa562" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityAddressPostalZipCode_2dae2c23-5e1c-4655-8a12-10b46a8fa562" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_98bf74db-a33d-4752-ba6d-09ffdc2ea793" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_CityAreaCode_98bf74db-a33d-4752-ba6d-09ffdc2ea793" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_b0f03cb6-9c47-4513-b24d-75b6d3f6c480" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_LocalPhoneNumber_b0f03cb6-9c47-4513-b24d-75b6d3f6c480" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_bc163722-be03-4d97-b41a-faa49955ff78" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_WrittenCommunications_bc163722-be03-4d97-b41a-faa49955ff78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_4e393a0c-b6f0-46ee-9e80-9616557f3427" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_SolicitingMaterial_4e393a0c-b6f0-46ee-9e80-9616557f3427" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_91fee6db-0ada-4447-8f73-8b7541ced46a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_PreCommencementTenderOffer_91fee6db-0ada-4447-8f73-8b7541ced46a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_0949d4b1-6e90-4f57-9d3d-bb35c262e2a6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_0949d4b1-6e90-4f57-9d3d-bb35c262e2a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_3c2198b9-ced0-4f88-a050-558ab24575bb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_Security12bTitle_3c2198b9-ced0-4f88-a050-558ab24575bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_3a304c2b-14d8-4bf1-93c2-15c0e8df738f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_TradingSymbol_3a304c2b-14d8-4bf1-93c2-15c0e8df738f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_21845c53-ab8a-44d0-bd98-59030793ac44" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_SecurityExchangeName_21845c53-ab8a-44d0-bd98-59030793ac44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_3e0315e8-5980-4dd1-9200-b7024cc3bf73" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityEmergingGrowthCompany_3e0315e8-5980-4dd1-9200-b7024cc3bf73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_788f16e0-996c-41be-9cde-ddda86d001b6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb59f63d-d6ae-4aea-ba41-e2dd68a677fa" xlink:to="loc_dei_EntityExTransitionPeriod_788f16e0-996c-41be-9cde-ddda86d001b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
