<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:1dd6a09f-554c-4284-8d74-ec7cee0e761c,g:3b306387-519e-45fb-8aab-09f1a186affa-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/Cover" xlink:type="simple" xlink:href="sibn-20211108.xsd#Cover"/>
  <link:presentationLink xlink:role="http://si-bone.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_45debce0-b023-4e03-843b-460031da691f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_DocumentType_45debce0-b023-4e03-843b-460031da691f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_641d15fd-f70e-43bd-8c19-b3f9fc94c782" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_DocumentPeriodEndDate_641d15fd-f70e-43bd-8c19-b3f9fc94c782" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_e23ac573-1785-48a7-bfef-c407f0a24fe6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityRegistrantName_e23ac573-1785-48a7-bfef-c407f0a24fe6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_260fd2b1-09d1-494a-a376-e79fff5abfd0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityCentralIndexKey_260fd2b1-09d1-494a-a376-e79fff5abfd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_e612e688-6c1a-4657-abe5-f84e03ead2a6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_AmendmentFlag_e612e688-6c1a-4657-abe5-f84e03ead2a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_d635daa9-4d42-4485-a36f-97a4de7fc8bb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityIncorporationStateCountryCode_d635daa9-4d42-4485-a36f-97a4de7fc8bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_4c33f8d9-c0a8-4bb5-a155-fa0bb45dc31c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityFileNumber_4c33f8d9-c0a8-4bb5-a155-fa0bb45dc31c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_eba08dee-83c5-47e6-b32e-a83fef1eb030" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityTaxIdentificationNumber_eba08dee-83c5-47e6-b32e-a83fef1eb030" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_0df1ff52-a0ff-4ce5-86f8-73832b5fc975" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityAddressAddressLine1_0df1ff52-a0ff-4ce5-86f8-73832b5fc975" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_a821ada2-5c55-46d3-b03a-c47116ea91ee" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityAddressAddressLine2_a821ada2-5c55-46d3-b03a-c47116ea91ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_edeaef84-ada4-4f9c-99d9-e783e3f8cf05" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityAddressCityOrTown_edeaef84-ada4-4f9c-99d9-e783e3f8cf05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_4b768769-c92d-40ab-9932-69f5d8429a5d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityAddressStateOrProvince_4b768769-c92d-40ab-9932-69f5d8429a5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_8cdaf037-fa3d-4539-89d7-a7431c768216" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityAddressPostalZipCode_8cdaf037-fa3d-4539-89d7-a7431c768216" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_4e682614-d66c-479e-bef5-b93bec0e2d16" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_CityAreaCode_4e682614-d66c-479e-bef5-b93bec0e2d16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_842bbd92-364e-4b9c-bca9-f7c4478e4574" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_LocalPhoneNumber_842bbd92-364e-4b9c-bca9-f7c4478e4574" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_4e5cf3a8-5c36-4f04-a3d8-e034474e9c1b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_WrittenCommunications_4e5cf3a8-5c36-4f04-a3d8-e034474e9c1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_95f5b304-5496-4392-a2e2-e2b00320d69e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_SolicitingMaterial_95f5b304-5496-4392-a2e2-e2b00320d69e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_48233e8c-d664-4317-992d-0a82b7907fb2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_PreCommencementTenderOffer_48233e8c-d664-4317-992d-0a82b7907fb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_1e0922a8-8ad9-4228-8740-1678e7d10915" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_1e0922a8-8ad9-4228-8740-1678e7d10915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_51e2d23e-6653-4017-8aee-f43f6937e024" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_Security12bTitle_51e2d23e-6653-4017-8aee-f43f6937e024" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_fd110ac6-2c2e-4ba3-bdab-36d1c6d6e551" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_TradingSymbol_fd110ac6-2c2e-4ba3-bdab-36d1c6d6e551" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_203d9181-edf3-45be-8002-a2d709c2682f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_SecurityExchangeName_203d9181-edf3-45be-8002-a2d709c2682f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_60a96730-ad62-4778-af70-1796c5563817" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityEmergingGrowthCompany_60a96730-ad62-4778-af70-1796c5563817" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_43603d94-dda2-4490-929a-f8edb1d4966b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_826a9a4b-4207-4228-a6f5-bab2405ccc1a" xlink:to="loc_dei_EntityExTransitionPeriod_43603d94-dda2-4490-929a-f8edb1d4966b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
