<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:29984a98-4f50-47ee-b1b8-1bb9c42fb019,g:344717ed-269f-4f80-9a3d-59cf132f936d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/Cover" xlink:type="simple" xlink:href="sibn-20210503.xsd#Cover"/>
  <link:presentationLink xlink:role="http://si-bone.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_14fc4cbe-7f82-4f40-8698-4d5819d3c5bd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_DocumentType_14fc4cbe-7f82-4f40-8698-4d5819d3c5bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_2a034c74-377f-41aa-a37e-fff85fd1af38" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_DocumentPeriodEndDate_2a034c74-377f-41aa-a37e-fff85fd1af38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_4c0d837e-4591-462d-a70d-38f0efbe84f0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityRegistrantName_4c0d837e-4591-462d-a70d-38f0efbe84f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_e3817e18-0682-4ec1-ab12-fe3aec9702e7" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityCentralIndexKey_e3817e18-0682-4ec1-ab12-fe3aec9702e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_62cc0e9b-7f11-4e78-a1c8-ee67b145eed2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_AmendmentFlag_62cc0e9b-7f11-4e78-a1c8-ee67b145eed2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_be990398-04a7-49e0-bf22-f326a5150160" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityIncorporationStateCountryCode_be990398-04a7-49e0-bf22-f326a5150160" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_90db491d-861d-4d18-89b1-a381ae34bdf4" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityFileNumber_90db491d-861d-4d18-89b1-a381ae34bdf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_25caf6e0-8d0b-41c4-9336-18b101f97161" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityTaxIdentificationNumber_25caf6e0-8d0b-41c4-9336-18b101f97161" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_1923887e-bfd6-451d-b1de-bf3ee400e531" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityAddressAddressLine1_1923887e-bfd6-451d-b1de-bf3ee400e531" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_7adb908c-eff1-43eb-a9e2-593ed8e6c084" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityAddressAddressLine2_7adb908c-eff1-43eb-a9e2-593ed8e6c084" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_34eec2a3-9a7f-47f0-9060-3827508a7307" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityAddressCityOrTown_34eec2a3-9a7f-47f0-9060-3827508a7307" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_424c3c57-75ce-4562-8f3f-7f1e40255d70" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityAddressStateOrProvince_424c3c57-75ce-4562-8f3f-7f1e40255d70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_928f7699-c250-4acc-9513-7d61c829aa87" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityAddressPostalZipCode_928f7699-c250-4acc-9513-7d61c829aa87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_cafabbd5-c3bb-4bdc-9a6a-fa42ed35dc58" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_CityAreaCode_cafabbd5-c3bb-4bdc-9a6a-fa42ed35dc58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_d135376f-6470-4203-9425-c3960e677d35" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_LocalPhoneNumber_d135376f-6470-4203-9425-c3960e677d35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_1145cae3-547d-4af8-be6c-c391a1997c34" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_WrittenCommunications_1145cae3-547d-4af8-be6c-c391a1997c34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_e251f972-a2c1-461f-9401-c32281c8056c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_SolicitingMaterial_e251f972-a2c1-461f-9401-c32281c8056c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_ae054c5e-94e6-4753-8337-5383fed1cf2b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_PreCommencementTenderOffer_ae054c5e-94e6-4753-8337-5383fed1cf2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_da124be0-cd6d-4879-a62b-3b544968fef3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_da124be0-cd6d-4879-a62b-3b544968fef3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_93d2f3a9-958d-448e-83c8-c18a9b2e843c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_Security12bTitle_93d2f3a9-958d-448e-83c8-c18a9b2e843c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_82a7a941-0be6-44fa-b0b8-f2617fa18641" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_TradingSymbol_82a7a941-0be6-44fa-b0b8-f2617fa18641" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_87ada7d2-a6a6-48a0-b1d3-0c36b06e3b52" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_SecurityExchangeName_87ada7d2-a6a6-48a0-b1d3-0c36b06e3b52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_67409245-883b-46a9-870c-ff469f02da25" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityEmergingGrowthCompany_67409245-883b-46a9-870c-ff469f02da25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_52a8d72a-1ed5-4869-be6e-a00318cdcec7" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_c6140370-02d6-46a1-94ea-3cb5a1336773" xlink:to="loc_dei_EntityExTransitionPeriod_52a8d72a-1ed5-4869-be6e-a00318cdcec7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
