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  <xs:element id="sibn_DebtInstrumentPrepaymentPremiumYearTwoPercentage" abstract="false" name="DebtInstrumentPrepaymentPremiumYearTwoPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_OptionsTrancheFourMember" abstract="true" name="OptionsTrancheFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_OptionsTrancheFiveMember" abstract="true" name="OptionsTrancheFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax" abstract="false" name="AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_RevenueRecognitionStandardPaymentTerms" abstract="false" name="RevenueRecognitionStandardPaymentTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="sibn_DevelopmentAgreementMember" abstract="true" name="DevelopmentAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_OptionsTrancheOneMember" abstract="true" name="OptionsTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationVestingOfEarlyExercisedStockOptions" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationVestingOfEarlyExercisedStockOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriods" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriods" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriodInterval" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriodInterval" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="sibn_WarrantsIssuedNovemberNinthTwentyFifteenMember" abstract="true" name="WarrantsIssuedNovemberNinthTwentyFifteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtInstrumentFeeAmountAsPercentageOfAggregatePrincipal" abstract="false" name="DebtInstrumentFeeAmountAsPercentageOfAggregatePrincipal" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_PayrollProtectionProgramLoanCARESActMember" abstract="true" name="PayrollProtectionProgramLoanCARESActMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_OperatingLossCarryforwardsLimited" abstract="false" name="OperatingLossCarryforwardsLimited" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_OptionsTrancheTwoMember" abstract="true" name="OptionsTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_OptionsTrancheThreeMember" abstract="true" name="OptionsTrancheThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtInstrumentPrepaymentPremiumYearThreeOrLaterPercentage" abstract="false" name="DebtInstrumentPrepaymentPremiumYearThreeOrLaterPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_FollowOnPublicOfferingMember" abstract="true" name="FollowOnPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOwnershipOfOutstandingSharesThresholdForAlternateTerms" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOwnershipOfOutstandingSharesThresholdForAlternateTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sibn_MarketableSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" abstract="false" name="MarketableSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sibn_IncentiveStockOptionMember" abstract="true" name="IncentiveStockOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_LesseeOperatingLeaseLeaseNotYetCommencedNumberOfOptionsToExtend" abstract="false" name="LesseeOperatingLeaseLeaseNotYetCommencedNumberOfOptionsToExtend" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="sibn_ESPPPurchaseRightsMember" abstract="true" name="ESPPPurchaseRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_A2018EquityIncentivePlanMember" abstract="true" name="A2018EquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_Company401KPlanMember" abstract="true" name="Company401KPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sibn_DebtPrepaymentPenaltyPeriodAxis" abstract="true" name="DebtPrepaymentPenaltyPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="sibn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisePriceAsPercentOfFairMarketValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisePriceAsPercentOfFairMarketValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
</xs:schema>
