<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:1a9c28bf-7b42-4f84-86ac-8e5009db98a1,g:ac35450e-988b-4904-9741-d55cf19aa8f1-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="sibn-20250630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_e8810d28-ced9-466c-a615-f8daaa087097" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_b219ad54-4a5e-4449-ba3c-36469c391c46" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e8810d28-ced9-466c-a615-f8daaa087097" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_b219ad54-4a5e-4449-ba3c-36469c391c46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_1fd98e8b-aeeb-430e-9bf1-76a50706d805" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e8810d28-ced9-466c-a615-f8daaa087097" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_1fd98e8b-aeeb-430e-9bf1-76a50706d805" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_a1f98f73-2fbd-430f-baf4-6a3f0fd79a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e8810d28-ced9-466c-a615-f8daaa087097" xlink:to="loc_us-gaap_AccountsPayableCurrent_a1f98f73-2fbd-430f-baf4-6a3f0fd79a8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_edd255f0-4906-4827-9e93-ae0c520a62dd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_90446fa7-0dc3-4ddf-b44b-62bd7c9ba6b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_edd255f0-4906-4827-9e93-ae0c520a62dd" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_90446fa7-0dc3-4ddf-b44b-62bd7c9ba6b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_2385899d-6ea9-464e-9ec3-7fb257acfa05" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_edd255f0-4906-4827-9e93-ae0c520a62dd" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_2385899d-6ea9-464e-9ec3-7fb257acfa05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_0ab65c7d-8a46-443f-b92c-1a7e40c305f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_edd255f0-4906-4827-9e93-ae0c520a62dd" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_0ab65c7d-8a46-443f-b92c-1a7e40c305f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_4cababcf-aa5c-4797-98c0-3eadcfc9984d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_edd255f0-4906-4827-9e93-ae0c520a62dd" xlink:to="loc_us-gaap_LiabilitiesCurrent_4cababcf-aa5c-4797-98c0-3eadcfc9984d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_3f029b83-4edf-4dfa-90dd-1652bc9c8027" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8eacdf13-df8c-46f7-a72a-b32b3c0dcf2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_3f029b83-4edf-4dfa-90dd-1652bc9c8027" xlink:to="loc_us-gaap_Liabilities_8eacdf13-df8c-46f7-a72a-b32b3c0dcf2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_96700e8a-3ab0-47b1-8eb7-61fb6066d004" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_3f029b83-4edf-4dfa-90dd-1652bc9c8027" xlink:to="loc_us-gaap_CommitmentsAndContingencies_96700e8a-3ab0-47b1-8eb7-61fb6066d004" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_a16210cc-a84b-4040-8cc6-4cb88b18722c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_3f029b83-4edf-4dfa-90dd-1652bc9c8027" xlink:to="loc_us-gaap_StockholdersEquity_a16210cc-a84b-4040-8cc6-4cb88b18722c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_4169ed87-4ac4-4b6a-99fb-e98c91d6eb6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_80d49651-aedd-4a8b-9e42-fed30e3d01fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4169ed87-4ac4-4b6a-99fb-e98c91d6eb6f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_80d49651-aedd-4a8b-9e42-fed30e3d01fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_2eb13442-cff2-499f-9bd4-73d080920630" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4169ed87-4ac4-4b6a-99fb-e98c91d6eb6f" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_2eb13442-cff2-499f-9bd4-73d080920630" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_9197856e-e24e-479f-a8d3-78d42cdb206a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4169ed87-4ac4-4b6a-99fb-e98c91d6eb6f" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_9197856e-e24e-479f-a8d3-78d42cdb206a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_72ee7827-8393-4e1b-bcd9-969a90238751" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4169ed87-4ac4-4b6a-99fb-e98c91d6eb6f" xlink:to="loc_us-gaap_InventoryNet_72ee7827-8393-4e1b-bcd9-969a90238751" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_070c8d2b-218b-4017-b5ad-69e3690e2acb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4169ed87-4ac4-4b6a-99fb-e98c91d6eb6f" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_070c8d2b-218b-4017-b5ad-69e3690e2acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_334d525c-bafb-4850-b0ab-389253afb098" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_25186a73-8794-4803-a7e0-105385744ab4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_334d525c-bafb-4850-b0ab-389253afb098" xlink:to="loc_us-gaap_AssetsCurrent_25186a73-8794-4803-a7e0-105385744ab4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_47a2fc2b-6e7b-4e35-9dfe-e30f59fa771c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_334d525c-bafb-4850-b0ab-389253afb098" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_47a2fc2b-6e7b-4e35-9dfe-e30f59fa771c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_c81509e0-705d-48d0-9643-8af6de0fcb22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_334d525c-bafb-4850-b0ab-389253afb098" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_c81509e0-705d-48d0-9643-8af6de0fcb22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_3b39886e-355d-4cad-9198-f4b7b4479e03" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_334d525c-bafb-4850-b0ab-389253afb098" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_3b39886e-355d-4cad-9198-f4b7b4479e03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9a851721-b40f-4797-8cc1-c71d6ed67c82" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_49bf8b7a-e067-4746-8ea9-c6e77f5a0f53" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9a851721-b40f-4797-8cc1-c71d6ed67c82" xlink:to="loc_us-gaap_PreferredStockValue_49bf8b7a-e067-4746-8ea9-c6e77f5a0f53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_84b53368-57f9-4311-a9ab-c04db42496fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9a851721-b40f-4797-8cc1-c71d6ed67c82" xlink:to="loc_us-gaap_CommonStockValue_84b53368-57f9-4311-a9ab-c04db42496fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_a1bc1c5e-ab5a-4e16-af6c-58ffdd9cdf5b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9a851721-b40f-4797-8cc1-c71d6ed67c82" xlink:to="loc_us-gaap_AdditionalPaidInCapital_a1bc1c5e-ab5a-4e16-af6c-58ffdd9cdf5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_df4952c2-23f4-4ea5-846e-915a54f7561e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9a851721-b40f-4797-8cc1-c71d6ed67c82" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_df4952c2-23f4-4ea5-846e-915a54f7561e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_61918bb4-becf-44f4-9399-3ffa83950148" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9a851721-b40f-4797-8cc1-c71d6ed67c82" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_61918bb4-becf-44f4-9399-3ffa83950148" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="sibn-20250630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_8a032a8a-24ad-432d-b7c9-fd6f70d81d8d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_846b392f-e01b-4657-a24e-501b554f18f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_8a032a8a-24ad-432d-b7c9-fd6f70d81d8d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_846b392f-e01b-4657-a24e-501b554f18f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_001f819a-918c-4045-bba6-5bfe8bdcee08" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_8a032a8a-24ad-432d-b7c9-fd6f70d81d8d" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_001f819a-918c-4045-bba6-5bfe8bdcee08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_92f10236-1130-4182-a91e-4182bcc15d60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_0c40ac0d-25ad-4308-8a76-81266ec3757b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_92f10236-1130-4182-a91e-4182bcc15d60" xlink:to="loc_us-gaap_GrossProfit_0c40ac0d-25ad-4308-8a76-81266ec3757b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_bd395aa5-beda-48ce-b929-c2ca822c9414" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_92f10236-1130-4182-a91e-4182bcc15d60" xlink:to="loc_us-gaap_OperatingExpenses_bd395aa5-beda-48ce-b929-c2ca822c9414" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_5049769b-9052-4fad-b5e1-bb1e89798533" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6d1c0a83-87e2-470b-ae31-532066db794d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_5049769b-9052-4fad-b5e1-bb1e89798533" xlink:to="loc_us-gaap_NetIncomeLoss_6d1c0a83-87e2-470b-ae31-532066db794d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_774f91da-c6d0-4aa6-9a1c-1e47ceeafc06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_5049769b-9052-4fad-b5e1-bb1e89798533" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_774f91da-c6d0-4aa6-9a1c-1e47ceeafc06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_fb485bb8-0165-4558-b428-37edf7a2fb50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_5049769b-9052-4fad-b5e1-bb1e89798533" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_fb485bb8-0165-4558-b428-37edf7a2fb50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_d1b17939-a8cb-4aef-8193-0a73d3d10f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_0972f156-0cb0-4831-abc5-7ed2f43b8e06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_d1b17939-a8cb-4aef-8193-0a73d3d10f8f" xlink:to="loc_us-gaap_SellingAndMarketingExpense_0972f156-0cb0-4831-abc5-7ed2f43b8e06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_93208cae-8676-42f0-aa0d-636ab5838ddb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_d1b17939-a8cb-4aef-8193-0a73d3d10f8f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_93208cae-8676-42f0-aa0d-636ab5838ddb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_889549cf-8e63-4a1d-a666-a50cd3e9563a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_d1b17939-a8cb-4aef-8193-0a73d3d10f8f" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_889549cf-8e63-4a1d-a666-a50cd3e9563a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_86f28089-316e-44a5-85e2-8514ed4a8bdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_8e123db2-c35c-4703-a3fa-a59c003289b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_86f28089-316e-44a5-85e2-8514ed4a8bdf" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_8e123db2-c35c-4703-a3fa-a59c003289b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_72a5f179-d4ac-41b7-8705-4272e022b71d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_86f28089-316e-44a5-85e2-8514ed4a8bdf" xlink:to="loc_us-gaap_OperatingIncomeLoss_72a5f179-d4ac-41b7-8705-4272e022b71d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_e5eed52c-26b7-4234-9b19-5f2d431570a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_86f28089-316e-44a5-85e2-8514ed4a8bdf" xlink:to="loc_us-gaap_InterestExpenseNonoperating_e5eed52c-26b7-4234-9b19-5f2d431570a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_2028b764-0f81-47ac-ae7e-84f02140c1f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_86f28089-316e-44a5-85e2-8514ed4a8bdf" xlink:to="loc_us-gaap_InvestmentIncomeInterest_2028b764-0f81-47ac-ae7e-84f02140c1f7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="sibn-20250630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_261e5d25-c42f-4374-829c-1a7c5efbfe85" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_NetIncomeLoss_261e5d25-c42f-4374-829c-1a7c5efbfe85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_375c3f53-2cab-4d3d-8a4f-5bb9a8ccb7e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_ShareBasedCompensation_375c3f53-2cab-4d3d-8a4f-5bb9a8ccb7e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_f5415a01-ee20-4524-a9fd-f9ffe5c17fc2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_f5415a01-ee20-4524-a9fd-f9ffe5c17fc2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_29f886a6-d12e-413e-88d2-1945005f923a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_29f886a6-d12e-413e-88d2-1945005f923a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_252dac82-08dd-4d7c-91c2-e3374eeb2b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_252dac82-08dd-4d7c-91c2-e3374eeb2b3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_75a80682-f20e-4092-80ba-4d0e3d567b97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_75a80682-f20e-4092-80ba-4d0e3d567b97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_6511ab7c-e367-4f4b-9e16-d97221e97163" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_6511ab7c-e367-4f4b-9e16-d97221e97163" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_3f9c5b92-6ae6-4215-886f-833316824876" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_3f9c5b92-6ae6-4215-886f-833316824876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_96b5c6cf-1ab2-4401-92c7-6f66d400abde" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_96b5c6cf-1ab2-4401-92c7-6f66d400abde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_e2738973-502a-46f7-81b8-b80a6e1e509c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_e2738973-502a-46f7-81b8-b80a6e1e509c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_258154da-e2ad-4bbf-bfa9-f5a3a288b35e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_258154da-e2ad-4bbf-bfa9-f5a3a288b35e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_f74a0687-1b27-436f-a932-dd08a0761238" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_f74a0687-1b27-436f-a932-dd08a0761238" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_a2b43086-8375-488f-9454-65d3d636c82a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_454ccc8c-676a-47e0-bc6a-36be233fe12b" xlink:to="loc_us-gaap_InventoryWriteDown_a2b43086-8375-488f-9454-65d3d636c82a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0588ab0b-bc36-4ece-b24c-5703fa7ff249" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_dad1e8ce-56d4-4a5a-bd66-ed17af85fe07" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0588ab0b-bc36-4ece-b24c-5703fa7ff249" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_dad1e8ce-56d4-4a5a-bd66-ed17af85fe07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fbbcc69c-623f-43bf-a2a9-51ef85c3a8e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0588ab0b-bc36-4ece-b24c-5703fa7ff249" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fbbcc69c-623f-43bf-a2a9-51ef85c3a8e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3e46ae6d-adf5-48a2-b626-8fabf428ea4e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0588ab0b-bc36-4ece-b24c-5703fa7ff249" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3e46ae6d-adf5-48a2-b626-8fabf428ea4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c96d58de-caad-488e-a0a6-a6918b985a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0588ab0b-bc36-4ece-b24c-5703fa7ff249" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c96d58de-caad-488e-a0a6-a6918b985a1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ce8a4f43-a7b9-4c4e-94b3-5af72c988113" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_ProceedsFromMaturityOfMarketableSecurities_1512e9a1-e85f-427b-b313-7d8b234cd203" xlink:href="sibn-20250630.xsd#sibn_ProceedsFromMaturityOfMarketableSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ce8a4f43-a7b9-4c4e-94b3-5af72c988113" xlink:to="loc_sibn_ProceedsFromMaturityOfMarketableSecurities_1512e9a1-e85f-427b-b313-7d8b234cd203" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_e75ef614-a01c-4446-8ee1-ef7b866f24d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ce8a4f43-a7b9-4c4e-94b3-5af72c988113" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_e75ef614-a01c-4446-8ee1-ef7b866f24d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_48904348-ed70-4ff6-9da4-afe6575c14d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ce8a4f43-a7b9-4c4e-94b3-5af72c988113" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_48904348-ed70-4ff6-9da4-afe6575c14d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ec70d5aa-acc3-493e-ad4f-3adf881a9e02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_48643257-2e80-4d5f-a65b-3d8d30abf660" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ec70d5aa-acc3-493e-ad4f-3adf881a9e02" xlink:to="loc_us-gaap_ProceedsFromStockPlans_48643257-2e80-4d5f-a65b-3d8d30abf660" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_c6fcf10a-22e1-49a3-a31f-d4ea11d51ecb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ec70d5aa-acc3-493e-ad4f-3adf881a9e02" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_c6fcf10a-22e1-49a3-a31f-d4ea11d51ecb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/MarketableSecuritiesScheduleofMarketableSecuritiesDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#MarketableSecuritiesScheduleofMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/MarketableSecuritiesScheduleofMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_b8538b4c-6863-4975-9bd7-c8b6c9e687b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_546716cc-cc38-4c98-a177-18a2dc7f7bdc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_b8538b4c-6863-4975-9bd7-c8b6c9e687b3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_546716cc-cc38-4c98-a177-18a2dc7f7bdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1e050875-5812-465d-a644-4858f2746ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_b8538b4c-6863-4975-9bd7-c8b6c9e687b3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1e050875-5812-465d-a644-4858f2746ffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_459736c4-8e6c-425a-a9dd-cdb49c9f5b0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_b8538b4c-6863-4975-9bd7-c8b6c9e687b3" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_459736c4-8e6c-425a-a9dd-cdb49c9f5b0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_MarketableSecuritiesAmortizedCost_d4317781-db3c-4ef2-a5a8-ee9de76296ad" xlink:href="sibn-20250630.xsd#sibn_MarketableSecuritiesAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_d250db0d-c2dc-414f-b086-e927fc5c0a30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_d4317781-db3c-4ef2-a5a8-ee9de76296ad" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_d250db0d-c2dc-414f-b086-e927fc5c0a30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_fcc7fcf5-4731-4132-871b-3102b3f4553c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_d4317781-db3c-4ef2-a5a8-ee9de76296ad" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_fcc7fcf5-4731-4132-871b-3102b3f4553c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_faa4c6b9-e676-41ba-bae3-86ea737667d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_16c996b8-2e42-4c1a-bf14-1662f3f16130" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_faa4c6b9-e676-41ba-bae3-86ea737667d4" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_16c996b8-2e42-4c1a-bf14-1662f3f16130" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_d95305c9-045f-4814-80af-dce68c98e53f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_faa4c6b9-e676-41ba-bae3-86ea737667d4" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_d95305c9-045f-4814-80af-dce68c98e53f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#BalanceSheetComponentsPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_21e0e273-593c-42ef-8d17-7af7d71eb987" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_3a5b1585-a004-406e-ad0e-059f87de9779" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_21e0e273-593c-42ef-8d17-7af7d71eb987" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_3a5b1585-a004-406e-ad0e-059f87de9779" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_15fee379-41d3-4580-803f-023375fcb685" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_21e0e273-593c-42ef-8d17-7af7d71eb987" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_15fee379-41d3-4580-803f-023375fcb685" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsAccruedLiabilitiesandOtherDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#BalanceSheetComponentsAccruedLiabilitiesandOtherDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsAccruedLiabilitiesandOtherDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_f548488c-db90-4db3-94ca-f9e60534c805" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_b8676b1a-c860-4611-a374-d08a127e6033" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_f548488c-db90-4db3-94ca-f9e60534c805" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_b8676b1a-c860-4611-a374-d08a127e6033" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_7ed35cac-6b6a-4d44-97c4-ba3c2c0e6ccd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_f548488c-db90-4db3-94ca-f9e60534c805" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_7ed35cac-6b6a-4d44-97c4-ba3c2c0e6ccd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_df0a0d8f-4400-4167-8c89-210db142701d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_f548488c-db90-4db3-94ca-f9e60534c805" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_df0a0d8f-4400-4167-8c89-210db142701d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_cbb9dc21-7925-4700-9c82-d1b773eced55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_f548488c-db90-4db3-94ca-f9e60534c805" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_cbb9dc21-7925-4700-9c82-d1b773eced55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AccruedRebatesCurrent_947762e8-464a-4cbd-9fdd-207198cfa114" xlink:href="sibn-20250630.xsd#sibn_AccruedRebatesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_f548488c-db90-4db3-94ca-f9e60534c805" xlink:to="loc_sibn_AccruedRebatesCurrent_947762e8-464a-4cbd-9fdd-207198cfa114" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesSupplementalInformationRelatedtoLeaseExpenseDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#CommitmentsandContingenciesSupplementalInformationRelatedtoLeaseExpenseDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesSupplementalInformationRelatedtoLeaseExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_9016ea6f-3722-4964-81b8-8010e40e0571" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_1274f0fa-e9bd-468f-81c7-42f698b7b83a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_9016ea6f-3722-4964-81b8-8010e40e0571" xlink:to="loc_us-gaap_OperatingLeaseCost_1274f0fa-e9bd-468f-81c7-42f698b7b83a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_14dc1b71-9f59-487a-96f5-66dac804a611" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_9016ea6f-3722-4964-81b8-8010e40e0571" xlink:to="loc_us-gaap_VariableLeaseCost_14dc1b71-9f59-487a-96f5-66dac804a611" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b4c9563f-e833-4ead-ba3c-fe83aeeaa727" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_47d4e9af-4415-4762-afeb-7f8028f004c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b4c9563f-e833-4ead-ba3c-fe83aeeaa727" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_47d4e9af-4415-4762-afeb-7f8028f004c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_a4116820-61cd-4942-a7c8-74e158bc0fe0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b4c9563f-e833-4ead-ba3c-fe83aeeaa727" xlink:to="loc_us-gaap_OperatingLeaseLiability_a4116820-61cd-4942-a7c8-74e158bc0fe0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="sibn-20250630.xsd#CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_b9a223c5-646d-4d86-8d2c-6f7de4e0f2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_b9a223c5-646d-4d86-8d2c-6f7de4e0f2c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_0f7f72ca-a366-401b-8ff8-cf131234c8d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_0f7f72ca-a366-401b-8ff8-cf131234c8d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_41136e58-0bb9-46df-92af-9561d30b1068" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_41136e58-0bb9-46df-92af-9561d30b1068" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_9f199b6d-ecb6-4631-8d59-8ff89dcdcbb6" xlink:href="sibn-20250630.xsd#sibn_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:to="loc_sibn_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_9f199b6d-ecb6-4631-8d59-8ff89dcdcbb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_2cd7d4e0-8871-4056-892e-48e2cf49fcb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_2cd7d4e0-8871-4056-892e-48e2cf49fcb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_0c926596-dc63-4d17-bbf9-8006577e82dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_5ff3c6c6-0ca5-422d-bf7b-9dcfe16061f6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_0c926596-dc63-4d17-bbf9-8006577e82dc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#BorrowingsSummaryofBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_3f125262-ac46-4d31-997a-57d192a46fe4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_e3319fea-d010-4994-bca5-4edb90f6aa9a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_3f125262-ac46-4d31-997a-57d192a46fe4" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_e3319fea-d010-4994-bca5-4edb90f6aa9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_a50a02e7-650f-47cc-911f-93395f0ba9c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_3f125262-ac46-4d31-997a-57d192a46fe4" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_a50a02e7-650f-47cc-911f-93395f0ba9c4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsDebtMaturityDetails" xlink:type="simple" xlink:href="sibn-20250630.xsd#BorrowingsDebtMaturityDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsDebtMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_37281f2f-6c3f-4ffb-83bb-1005d0b4bce1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_9087448d-222d-4a9c-92d0-8014b3df7cde" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_37281f2f-6c3f-4ffb-83bb-1005d0b4bce1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_9087448d-222d-4a9c-92d0-8014b3df7cde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_e8b289db-b4ef-42b8-aac1-a03af927f431" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_37281f2f-6c3f-4ffb-83bb-1005d0b4bce1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_e8b289db-b4ef-42b8-aac1-a03af927f431" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_391c3c4f-0ddb-4cf4-806b-e7979cac70ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_37281f2f-6c3f-4ffb-83bb-1005d0b4bce1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_391c3c4f-0ddb-4cf4-806b-e7979cac70ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_15725bae-aa80-4f13-988a-056ef5247d02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_37281f2f-6c3f-4ffb-83bb-1005d0b4bce1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_15725bae-aa80-4f13-988a-056ef5247d02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_dd894e7d-bb41-41f7-b163-6618a4631a7d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_37281f2f-6c3f-4ffb-83bb-1005d0b4bce1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_dd894e7d-bb41-41f7-b163-6618a4631a7d" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
